Objective:To investigate the nursing experience of postoperative complications such as rectal fistula, peritoneal infection, urethral anastomotic fistula, intermuscular venous thrombosis of both legs, separation of skin and mucosa after radical prostatectomy with robot-assisted laparoscopy.Methods:The clinical data of a patient with multiple complications after radical robot-assisted laparoscopic prostatectomy were retrospectively analyzed. The patient was diagnosed with prostate cancer on August 18, 2023, and underwent robot-assisted laparoscopic radical prostatectomy on September 27, 2023. Rectal fistula occurred on the 3rd day after surgery, complicated with abdominal infection, urethral anastomotic fistula on the 6th day after surgery, followed by intramuscular venous thrombosis of both legs (acute stage) and separation of the skin and mucosa of the stoma. Nursing points include close observation of patients' abdominal drainage, body temperature and other changes, alert to complications, active thrombolysis and lower limb deep vein thrombosis care, timely assessment of patients' nutritional status, and formulation of individualized nutrition programs, standardized stoma care throughout the whole process, personalized psychological care, in order to ensure patients' physical and mental health.Results:The patient recovered and was discharged 37 days after surgery. Three months after surgery, a follow-up examination showed that the venous thrombosis in both lower limbs was organized, the stoma function was good, and the albumin level was 38.6g/L.Conclusion:Radical prostatectomy is traumatic, complicated and prone to complications. For patients with multiple complications and complicated conditions, medical care should closely observe the changes of the condition, adhere to multidisciplinary diagnosis and treatment, integrate the advantages of multiple disciplines, and formulate an individualized treatment plan, so as to maximize the long-term benefits of patients.