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Tissue inhibitor of metalloproteinase-1 (TIMP-1) as a prognostic biomarker in gastrointestinal cancer: a meta-analysis 期刊论文

编号：

4DC7576EF646478220D274D9F354CC93
作者：

Qin, Lili#^[1]Wang, Yueqi(王玥琦)^[1]Yang, Na^[1];Zhang, Yangyu^[1];Zhao, Tianye^[1];Wu, Yanhua(吴燕华)*^[1]Jiang, Jing(姜晶)*^[1]
语种：

英文
期刊：

PEERJ ISSN：2167-8359 2021 年 9 卷 ; FEB 16
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关键词：

Tissue inhibitor of metalloproteinase 1 Immunohistochemistry Enzyme linked immunosorbent assay Gastric cancer Colorectal cancer Prognosis Meta-analysis
摘要：

Background. Tissue inhibitor of metalloproteinase 1 (TIMP-1) has recently been shown to be dependent on or independent of Matrix metalloproteinases (MMPs) in its roles in tumorigenesis and progression. This appreciation has prompted various studies assessing the prognostic value of TIM P-1 in patients with gastrointestinal cancer, however, the conclusions were still inconsistent. The aim of this study was to assess the prognostic value of TIMP-1-immunohistochemistry (IHC) staining and pretreatment serum/plasma TIMP-1 level in gastrointestinal cancer survival as well as the association between TIMP-1 and clinicopathologic features.
Methods. The meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO; Registration NO. CRD42020185407) and followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. A highly sensitive literature search was performed in electronic databases including PubMed, EMBASE and the Cochrane Library. Heterogeneity analysis was conducted using both chi-square-based Q statistics and the I-2 test. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to assess the prognostic value of TIMP-1 using the fixed-effects model. Odds ratios (ORs) with 95% CIs were calculated to evaluate the associations between TIMP-1 and clinicopathological characteristics. The meta-analysis was conducted using STATA 12.0 software.
Results. A total of 3,958 patients from twenty-two studies were included in the meta-analysis. Elevated TIMP-1 levels were significantly associated with poor survival in gastrointestinal cancer (TIMP-1-IHC staining: HR = 2.04, 95% CI [1.59-2.61], I-2 = 35.7%, P-Q = 0.156; pretreatment serum/plasma TIMP-1 levels: HR = 2.02, 95% CI [1.80-2.28], I-2 = 0%, PQ = 0.630). Moreover, clinicopathological parameter data analysis showed that elevated TIMP-1 levels were significantly associated with lymph node metastasis (N1/N2/N3 vs NO: OR = 2.92, 95% CI [1.95-4.38]) and higher TNM stages (III/W vs I/II: OR = 2.73, 95% CI [1.23-6.04]).
Conclusion. Both TIMP-1-positive IHC staining and high serum/plasma TIMP-1 levels are poor prognostic factors for the survival of gastrointestinal cancer. In addition, TIMP-1 overexpression was correlated with more advanced clinicopathological features.
推荐引用方式
GB/T 7714：

Qin Lili,Wang Yueqi,Yang Na, et al. Tissue inhibitor of metalloproteinase-1 (TIMP-1) as a prognostic biomarker in gastrointestinal cancer: a meta-analysis [J].PEERJ,2021,9.
APA：

Qin Lili,Wang Yueqi,Yang Na,Zhang Yangyu,&Jiang Jing.(2021).Tissue inhibitor of metalloproteinase-1 (TIMP-1) as a prognostic biomarker in gastrointestinal cancer: a meta-analysis .PEERJ,9.
MLA：

Qin Lili, et al. "Tissue inhibitor of metalloproteinase-1 (TIMP-1) as a prognostic biomarker in gastrointestinal cancer: a meta-analysis" .PEERJ 9(2021).
入库时间：

3/24/2021 2:24:30 AM
更新时间：

3/24/2021 2:24:30 AM
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