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The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis 期刊论文 WOS高被引论文 WOS热点论文

编号：

84EC1E24E3DE2FE35D3A5E936946A8E0
作者：

Liu, Pinyi#^[1,2,3]Wang, Yanbing(王雁冰)#^[4]Yang, Ge^[2];Zhang, Qihe^[1,2];Meng, Lingbin^[5];Xin, Ying(辛颖)*^[2]Jiang, Xin(姜新)*^[1,3]
语种：

英文
期刊：

PHARMACOLOGICAL RESEARCH ISSN：1043-6618 2021 年 165 卷 ; MAR
收录：
关键词：

Short-chain fatty acids Inflammation Carcinogenesis Intestinal barrier Oxidative stress
摘要：

Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress, but convincing evidence in humans is still lacking. Two major SCFA signaling mechanisms have been identified: promotion of histone acetylation and activation of G-protein-coupled receptors. In this review, we introduce the production and metabolic characteristics of SCFAs, summarize the potential effects of SCFAs on the four aspects mentioned above and the possible mechanisms. SCFAs have been reported to exert a wide spectrum of positive effects and have a high potential for therapeutic use in human-related diseases.
推荐引用方式
GB/T 7714：

Liu Pinyi,Wang Yanbing,Yang Ge, et al. The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis [J].PHARMACOLOGICAL RESEARCH,2021,165.
APA：

Liu Pinyi,Wang Yanbing,Yang Ge,Zhang Qihe,&Jiang Xin.(2021).The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis .PHARMACOLOGICAL RESEARCH,165.
MLA：

Liu Pinyi, et al. "The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis" .PHARMACOLOGICAL RESEARCH 165(2021).
入库时间：

3/24/2021 2:03:34 AM
更新时间：

3/24/2021 2:03:34 AM

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