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Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases. 期刊论文

编号：

A3986AB85CF8DC99215DAEE38140D941
作者：

Ding Yi;Cao Qiuyu;Wu Xianglin;Jiang Youjin;Li Xiaoran;Xu Yu;Xu Min;Wang Tiange;Chen Yuhong;Zhao Zhiyun;Zheng Jie;Wang Shuangyuan;Lin Hong;Gu Xuejiang;Yan Li;Zhang Miao;Gao Zhengnan;Chen Lulu;Zeng Tianshu;Hu Ruying;Ye Zhen;Yu Xuefeng;Chen Gang;Su Qing;Mu Yiming;Tang Xulei;Wan Qin;Wang Guixia;Qin Guijun;Luo Zuojie;Qin Yingfen;Chen Li;Hou Xinguo;Huo Yanan;Li Qiang;Qiao Hong;Zhang Yinfei;Liu Chao;Wang Youmin;Wu Shengli;Yang Tao;Deng Huacong;Zhao Jiajun;Wang Weiqing;Ning Guang;Lu Jieli;Li Mian;Bi Yufang
地址：

(Ding Yi)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Cao Qiuyu)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Wu Xianglin)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Jiang Youjin)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Li Xiaoran)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Xu Yu)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Xu Min)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Wang Tiange)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Chen Yuhong)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Zhao Zhiyun)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Zheng Jie)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Wang Shuangyuan)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Lin Hong)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Gu Xuejiang)The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.,(Yan Li)Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.,(Zhang Miao)Affiliated Hospital of Guiyang Medical College, Guiyang, China.,(Gao Zhengnan)Dalian Municipal Central Hospital, Dalian, China.,(Chen Lulu)Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.,(Zeng Tianshu)Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.,(Hu Ruying)Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.,(Ye Zhen)Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.,(Yu Xuefeng)Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.,(Chen Gang)Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.,(Su Qing)Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Mu Yiming)Chinese People's Liberation Army General Hospital, Beijing, China.,(Tang Xulei)The First Hospital of Lanzhou University, Lanzhou, China.,(Wan Qin)The Affiliated Hospital of Southwest Medical University, Luzhou, China.,(Wang Guixia)The First Hospital of Jilin University, Changchun, China.,(Qin Guijun)The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.,(Luo Zuojie)The First Affiliated Hospital of Guangxi Medical University, Nanning, China.,(Qin Yingfen)The First Affiliated Hospital of Guangxi Medical University, Nanning, China.,(Chen Li)Qilu Hospital of Shandong University, Jinan, China.,(Hou Xinguo)Qilu Hospital of Shandong University, Jinan, China.,(Huo Yanan)Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.,(Li Qiang)The Second Affiliated Hospital of Harbin Medical University, Harbin, China.,(Qiao Hong)The Second Affiliated Hospital of Harbin Medical University, Harbin, China.,(Zhang Yinfei)Central Hospital of Shanghai Jiading District, Shanghai, China.,(Liu Chao)Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.,(Wang Youmin)The First Affiliated Hospital of Anhui Medical University, Hefei, China.,(Wu Shengli)Karamay Municipal People's Hospital, Xinjiang, China.,(Yang Tao)The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.,(Deng Huacong)The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.,(Zhao Jiajun)Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.,(Wang Weiqing)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Ning Guang)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Lu Jieli)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,(Li Mian)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: limian39@aliyun.com.,(Bi Yufang)Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: byf10784@rjh.com.cn.
语种：

英文
期刊：

JACC. Asia ISSN：2772-3747 2026 年 ; 2026-Aug-06
收录：
关键词：

albuminuria cardiovascular disease chronic kidney disease lifestyle metabolic risk factor urinary albumin-to-creatinine ratio (UACR)
摘要：

Albuminuria from low-grade to clinically elevated range confers cardiorenal risks.;The authors aimed to investigate the differential roles of lifestyle/metabolic factors in the association of fine-categorized and continuously measured urinary albumin-to-creatinine ratio (UACR) levels with cardiorenal outcomes.;A total of 82,509 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study were included, with a median follow-up of 3.0 years. Outcomes included incident cardiovascular disease (CVD), incident CKD, their composite, along with surrogate markers. Lifestyle factors included tobacco use, alcohol use, diet, physical activity and sleep. Metabolic factors included diabetes, hypertension, abdominal obesity, and elevated low-density lipoprotein cholesterol. Cox proportional hazard models were used to calculate hazard ratios.;Compared to the lowest UACR, participants with mildly elevated UACR (≥10 to <30 mg/g) had a 39% higher risk of composite cardiorenal outcomes (multivariable-adjusted HR: 1.39, 95% CI: 1.29-1.50), whereas those with clinically elevated UACR (≥30 mg/g) had over double the risk (HR: 2.29, 95% CI: 2.12-2.47). A nonlinear J-shaped association was observed between continuous UACR and cardiorenal outcomes (Pnonlinearity = 0.0009), with UACR ≥10 mg/g already conferring risks, a pattern also reflected by the deterioration of PREVENT score and estimated glomerular filtration rate. Optimal lifestyle and metabolic status generally attenuated CVD risk related to low-grade albuminuria, while improvement of the latter additionally decreased CVD and cardiorenal risk, even in clinically elevated albuminuria (additive Pinteraction <0.0001). Hypertension showed the largest relative contribution to cardiorenal risk, particularly in UACR <30 mg/g.;Our findings highlighted low-grade albuminuria as a key preventive window for cardiorenal outcomes requiring both aspects of modifiable risk factors, and the cardiovascular benefits of metabolic improvement in established albuminuria.;
推荐引用方式
GB/T 7714：

Ding Yi,Cao Qiuyu,Wu Xianglin, et al. Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases. [J].JACC. Asia,2026.
APA：

Ding Yi,Cao Qiuyu,Wu Xianglin,Jiang Youjin,&Bi Yufang.(2026).Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases. .JACC. Asia.
MLA：

Ding Yi, et al. "Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases." .JACC. Asia(2026).
入库时间：

9/3/2026 9:26:19 PM
更新时间：

9/4/2026 2:16:33 AM

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