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供者年龄与HLA匹配孰更关键?重型再生障碍性贫血移植供者选择的新证据（英文）期刊论文

编号：

C7243894E8EAA79E6D8A55751CA4E4EA
作者：

徐郑丽^[1];许兰平;王顺清;吴德沛;张曦;高素君夏凌辉;葸瑞;杨建民;刘启发;江明;房孝生;马晓迪;黄晓军;
地址：

Peking University People's Hospital,Peking University Institute of Hematology;National Clinical Research Center for Hematologic Disease;Department of Hematology,Guangzhou First People's Hospital;Department of Hematology,The First Affiliated Hospital of Soochow University;Medical Center of Hematology,Institute of Science Innovation for Blood Ecology and Intelligent Cells,Xinqiao Hospital of Army Medical University;Department of Hematology,The First Hospital of Jilin University;Department of Hematology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology;Department of Hematology,General Hospital of Lanzhou Military Region of PLA;Department of Hematology,Changhai Hospital Affiliated to Second Military Medical University;Department of Hematology,Nanfang Hospital Affiliated to Southern Medical University;Department of Hematology,The First Affiliated Hospital of Xinjiang Medical University;Department of Hematology,Shandong Provincial Hospital;Beijing Key Laboratory of Hematopoietic St...
语种：

中文
期刊：

Science Bulletin ISSN：2095-9273 2026 年 71 卷 5 期 (1195 - 1203) ; 2026年3月
收录：
关键词：

Severe aplastic anemia Best donor Allogeneic Haploidentical
摘要：

Allogeneic hematopoietic stem cell transplantation(allo-HSCT) is a curative therapy for severe aplastic anemia(SAA), with donor sources including matched sibling donors(MSDs), haploidentical donors(HIDs), and unrelated donors(URDs). However, the optimal criteria for donor selection remain undefined.We performed a multicenter retrospective study of 795 consecutive SAA patients who underwent alloHSCT between 2012 and 2020 across 11 transplant centers in China. The overall survival(OS), failurefree survival(FFS), and GVHD-free/FFS(GFFS) rates were 85.2%, 83.6%, and 76.1%, respectively. Donorrelated variables including relationship, age, sex match, blood type, and HLA mismatches were evaluated.Multivariable Cox regression identified donor age ≥50 years as an independent risk factor for inferior GFFS(HR = 2.13), OS(HR = 2.09), and FFS(HR = 2.18)(all P < 0.001). To directly compare the prognostic weight of donor age versus HLA compatibility, we stratified patients into four subgroups according to donor type(HID vs....
推荐引用方式
GB/T 7714：

徐郑丽,许兰平,王顺清, 等. 供者年龄与HLA匹配孰更关键?重型再生障碍性贫血移植供者选择的新证据（英文） [J].Science Bulletin,2026,71(5):1195-1203.
APA：

徐郑丽,许兰平,王顺清,吴德沛,&黄晓军.(2026).供者年龄与HLA匹配孰更关键?重型再生障碍性贫血移植供者选择的新证据（英文） .Science Bulletin,71(5):1195-1203.
MLA：

徐郑丽, et al. "供者年龄与HLA匹配孰更关键?重型再生障碍性贫血移植供者选择的新证据（英文）" .Science Bulletin 71,5(2026):1195-1203.
入库时间：

7/13/2026 10:02:42 PM
更新时间：

7/13/2026 10:02:42 PM

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供者年龄与HLA匹配孰更关键?重型再生障碍性贫血移植供者选择的新证据（英文） 期刊论文

供者年龄与HLA匹配孰更关键?重型再生障碍性贫血移植供者选择的新证据（英文）期刊论文