In this study, we aimed to overcome poor osseointegration at the implant-bone interface by engineering a bioactive interface using the polymer-induced liquid precursor strategy. By systematically modulating mineralization parameters, we constructed biomimetic mineralized collagen (BMC)-modified interfaces on 3D porous titanium alloy implants. The optimized composite interface exhibited homogeneous mineralized collagen distribution and significantly enhanced physicochemical properties, including a 32 degrees reduction in water contact angle, along with 1.6- and 1.4-fold increases in histone and albumin adsorption, respectively. These modifications promoted cell adhesion and osteogenic differentiation, as evidenced by 1.8-fold higher mineral deposition, 2.4-fold elevated ALP activity, and upregulated ALP, RUNX-2, BMP-2, and Col I expression. In a rabbit femoral condyle defect model, the BMC-modified interface upregulated osteogenesis-related genes (RUNX-2, ALP, and BMP-2) and increased the mineral apposition rate by 33%. It also enhanced new bone volume within the implant by 55%, improved bone formation in defect regions by 38%, and increased interfacial bonding strength by 2.8-fold. These findings provide a theoretical foundation and demonstrate the clinical potential of this strategy for next-generation biofunctionalized orthopedic implants. (c) 2026 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
[1]Second Hosp Jilin Univ, Dept Orthoped, Changchun 130041, Peoples R China.
[2]First Hosp Jilin Univ, Dept Plast & Reconstruct Surg, Changchun 130021, Peoples R China.
(8.0+极速模式)